Please visit answersincme.com/GDJ860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in cardiology discusses strategies to reduce low-density lipoprotein cholesterol (LDL-C) in patients with severe familial hypercholesterolemia (FH). Upon completion of this activity, participants should be better able to: Describe the clinical impact of early and intensive treatment for patients with severe FH, including homozygous FH (HoFH); Discuss the clinical profiles of novel strategies to reduce LDL-C in patients with severe FH; and Outline guideline- and expert-recommended novel strategies across patient ages to reduce LDL-C in patients with severe FH.