High Intensity Health with Mike Mutzel, MS

Circadian Medicine: The Future of Fat Loss, Metabolic Health and Medicine


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Circadian rhythm optimization can improve metabolic health and support longevity. Learn ways to match lifestyle interventions with your circadian clock.

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Link to show notes and video: https://bit.ly/3a6Zo9D


Time Stamps: 


02:10 A dysregulated circadian clock system causes disease and dysfunction at the cellular level.

02:30 20%-50% of your protein synthesizing genes oscillate on a diurnal rhythm.

03:40 Disease alters the circadian clock system.

04:40 Blood sugar management supplements and pharmaceuticals would be best taken in the afternoon or evening, when blood sugar levels are most erratic.

05:03 Blood lipid level management supplements and pharmaceuticals would be best taken in the evening, when lipid synthesis occurs.

05:54 Decrease inflammatory tone before you go to sleep by doing some light yoga, breath work, take probiotics or curcuminoids.

07:30 Sleep perturbations cause dysbiosis in gut bacteria.

09:40 The intensity of your circadian rhythm is reduced as you age.

11:10 Circadian chronotypes influence the timing of cancer interventions.  

12:00 N-acetylcysteine and other antioxidants are best taken in the evening or before bed.

12:40 Results of studies may be inaccurate due to timing.

15:20 Shift workers have a higher incidence of cancer, metabolic disease, and obesity.

14:50 Cold, food, heat, meal timing and exercise influence your circadian clock system.

17:20 Menopause challenges the circadian clock system, reducing the amplitude of the rhythms.

18:40 Young people/children’s circadian rhythm is more light sensitive. Artificial light can be more problematic.

23:00 Fasting and feeding influence your circadian clock system. Break your fast between 11 and 1 pm when your digestive system is primed.

24:45 DHEA antagonizes cortisol’s synthesis and expression.

28:05 Darkness is a circadian cue. Exercise light hygiene.

31:25 Morning cold exposure and evening heat exposure enhances circadian amplitude.

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High Intensity Health with Mike Mutzel, MSBy Mike Mutzel shares interviews with Peter Attia, Jason Fung, Stan Efferding,

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