This Podcast discusses a study that aimed to evaluate the effect of the time interval and frequency of fluid overload-related hospitalizations on survival in peritoneal dialysis patients. Time intervals were classified in 12-month increments, and mortality rates were assessed. The study found that patients hospitalized due to fluid overload within the first 12 months of starting peritoneal dialysis had significantly higher mortality rates. A cumulative fluid-overload-free interval of less than 12 months also resulted in worse survival outcomes. Frequent hospitalizations due to fluid overload were strongly associated with higher mortality. The results emphasize the need for early and aggressive management of fluid overload.