Dr. Jon Cole and Dr. Samantha Lee from the Minnesota Regional Poison Center discuss how they support EMS providers treating opioid overdose and withdrawal in the field. They explain the Poison Center’s 24/7 role in guiding clinical decisions, managing concerns like precipitated withdrawal, and helping EMS providers feel confident when initiating buprenorphine. This episode highlights the critical partnership between EMS and toxicology in expanding access to evidence-based care.