Host Tara Lech is joined by Drs. Scott Woller and Virginia Silvari for a thoughtful conversation on anticoagulation stewardship: what it is, why it matters, and how it can help patients who need antithrombotic therapy. They share examples from their own practice, talk through common challenges, and offer simple steps for improving care across settings.

Topics:

• What makes anticoagulation stewardship different from traditional management

• How to choose the right anticoagulant for each patient

• Practical system-level steps to support safe prescribing

• Lessons from U.S. and European practices

• Tips for reassessing therapy and managing periprocedural care

Tune in now and subscribe to Clot, Clot, Who's There? for more expert conversations bridging science, practice, and global perspectives in thrombosis, hemostasis, and vascular medicine.

00:00 Welcome & Setting the Stage

02:01 What "Antithrombotic Stewardship" Really Means

05:49 Choosing the Right Agent for the Right Patient

13:39 Reassessment, Follow-Up, & Real-World Impact

22:50 Perioperative Management & Building a Stewardship Culture

Join host Christian Weber, MD (LMU Munich) with vascular biology experts Kimberly Martinod, PhD (University of Rochester) and Konstantin Stark, MD (LMU Munich) as they explore the evolving science of immunothrombosis and thromboinflammation—concepts that rose to prominence during COVID-19 but reach far beyond infectious disease.

Learn about:

• How thrombotic and inflammatory mechanisms impact cardiovascular disease, sepsis, and beyond
• Emerging biomarkers and therapies with the potential to improve patient outcomes
• The critical role of scientist–clinician collaboration in translating discoveries into care

For cardiologists, hematologists, critical care specialists—or anyone curious about immunity, clotting, and inflammation—this conversation provides both foundational insight and a forward-looking perspective.

Tune in now and subscribe to Clot, Clot, Who's There? for more expert conversations bridging science, practice, and global perspectives in thrombosis, hemostasis, and vascular medicine.

00:00 Welcome and Introductions 01:38 Immunothrombosis vs Thromboinflammation 04:00 How Cells & Molecules Interact 10:20 Clinical Impacts Across Diseases 13:29 Biomarkers & Translational Gaps 17:14 Emerging Therapies 22:04 Key Takeaways & Future Directions

Join JoMarie Monzon, NP (Cedars-Sinai, Vasculearn Network) as she welcomes moderator Dr. Cassra Arbabi and guests Drs. Donald Baril (Cedars-Sinai) and Efthymios (Makis) Avgerinos (Athens Medical Center) for a high-stakes discussion on acute limb ischemia (ALI). Explore U.S. and European approaches to this vascular emergency—from recognition to revascularization—and gain practical, globally informed insights on saving limbs and lives.

Topics covered:

• Recognizing the "six Ps" of ALI

• Why urgency is critical

• Imaging pathways in the U.S. and Europe

• Open vs. endovascular strategies, including thrombolysis

• Anticoagulation and supportive therapy

• Future directions in ALI management

Tune in now and subscribe to Clot, Clot, Who's There? for more expert conversations bridging science, practice, and global perspectives in thrombosis, hemostasis, and vascular medicine.

00:00 Introduction & Patient Case

05:05 Defining ALI and Why Time Is Limb

09:21 ALI Diagnosis & Early Management

13:47 Treatment Pathways

26:30 Beyond the OR

30:56 Key Takeaways

Dr. Bethany Samuelson Bannow is joined by Dr. Erik Klok and Dr. Geoff Barnes for a discussion on the best ways to communicate with your patients about anticoagulation. Anticoagulation therapy is a cornerstone of care for patients, but starting and managing these medications can be overwhelming for patients. In this episode, we'll cover common patient questions, tips for improving adherence, how to discuss lifestyle considerations and considering shared decision-making.

Today's episode is presented by the ISTH in partnership with Vasculearn Network. Vasculearn's podcast "Clot, Clot, Who's There?" is produced in partnership with the editors of the journal Thrombosis and Haemostasis at Thieme.

Join Dr. Jose Joglar, Chair of the 2023 U.S. AFib Guidelines, and Professor Gregory Lip, Chair of the ESC Council on Stroke, as they dive into the latest U.S. and European atrial fibrillation guidelines. From risk scores to rhythm control, they explore common ground, key differences, and the global shift toward holistic, patient-centered care. (Hint: coffee lovers with AFib, rejoice!)

Whether you're a clinician navigating daily treatment decisions or a curious learner keeping up with cardiology guidelines, this is a must-listen conversation that reveals how far we've come in managing AFib and where we're headed next.

Topics covered:

• Point-of-care pathways

• Anticoagulation and evolving risk scores

• Early rhythm control strategies

• Addressing AFib as a cardiometabolic disease

• Long-term impacts and future research priorities

Tune in now and subscribe to stay updated in expert insights in thrombosis and cardiovascular medicine!

For more resources, check out:

ESC Guidelines: Clinician Perspective: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-2434-9244 2024 ESC Guidelines: https://academic.oup.com/eurheartj/article/45/36/3314/7738779?login=false 2023 U.S. Guidelines: https://www.ahajournals.org/doi/10.1161/CIR.0000000000001193

00:00 Introduction 01:57 Philosophies Behind AFib Guidelines 08:11 Lifestyle and Prevention in AFib 08:58 Evidence for Holistic Care: mAFA & MIRACLE Trials 12:34 Stroke Risk Scores and Future Research Needs 17:29 Rhythm vs Rate Control: Evolving Practice 20:56 Ablation, Drug Therapy, and Shared Decision-Making 22:12 The Caffeine Myth 24:31 Key Takeaways

Join host Dr. Kerstin de Wit as she welcomes Drs. Cecilia Becattini and Behnood Bikdeli to unpack one of the most nuanced challenges in thrombosis care: venous thromboembolism (VTE) risk stratification and anticoagulation management.

This case-based conversation explores:

• How clinicians navigate decisions around continuing, reducing, or stopping anticoagulation

• Whether formal risk scores or D-dimer testing guide us—or just add noise

• The complexities of provoked vs. unprovoked VTE

• Approaches to shared decision-making

• Novel therapies on the horizon

Tune in now and subscribe to stay updated in expert insights in thrombosis and cardiovascular medicine!

Does sex influence the risk of atrial fibrillation (AF)-related strokes? Is female sex truly an independent risk factor? And what common myths still cloud clinical understanding?

In this episode, host Dr. Giulio Francesco Romiti (internal medicine specialist from Sapienza University of Rome, Italy) is joined by guests Dr. Geoff Barnes (cardiologist and vascular medicine specialist, University of Michigan, USA) and Dr. Bernadette Corica (internal medicine specialist and cardiologist in training in Modena, Italy, and honorary research fellow at the Liverpool Centre for Cardiovascular Science, UK) to explore the complex relationship between sex and stroke risk in patients with AF.

Together, they unpack the latest research, challenge myths and misconceptions, and provide key insights on:

✅ Sex disparities in AF prevalence and stroke incidence✅ Why women with AF may experience worse outcomes✅ The role of anticoagulation therapy in men vs. women✅ Practical clinical strategies for stroke prevention

Whether you're a clinician, researcher, or healthcare professional, this episode offers essential takeaways for optimizing patient care.

🎧 Tune in now and subscribe to stay updated on expert insights in thrombosis and cardiovascular medicine!

In this inaugural episode of Clot Clot Who's There, global experts Professor Tatjana Potpara (Serbia), and Dr. Annabelle Volgman (USA) join moderator Dr. Panteleimon Papakonstantinou (Ireland) to discuss the rising global prevalence of atrial fibrillation (AF), a leading contributor to strokes and heart failure. They explore regional differences in AF management, evolving guidelines, and the potential of new treatments and technologies. With a focus on prevention, disparities in care, and the importance of early and individualized interventions, this discussion highlights critical pathways to improving outcomes for AF patients worldwide.