Looking for the best College Football Week 1 bets and picks against the spread?
Matt opened the season with a perfect 3-0 record, while Bob and Chef stumbled to 1-2. Now the undefeated leader returns with five more picks, but the crew is directly divided on Colorado vs. Georgia Tech and No. 24 Louisville vs. No. 9 Ole Miss.
We break down our favorite Big 12 bets, national picks and gloriously questionable Sicko Locks for Week 1 of the 2026 college football season.
WEEK 0 RECORDS:
Matt: 3-0
Bob: 1-2
Chef: 1-2
WEEK 1 FEATURED PICKS:
• Colorado @ Georgia Tech
• Auburn vs. Baylor
• Oklahoma State @ Tulsa
• Louisville vs. Ole Miss
• LSU -10 vs. Clemson
Can Matt stay perfect? Who wins the Colorado-Georgia Tech disagreement? And which Sicko Lock is going to make us regret having this segment?
Drop your best College Football Week 1 bet in the comments and let us know which host you’re riding with.
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Cocaine Willie is the official K-State representative of The College Huddle.
Lines reflect the numbers available when the episode was recorded and may change. This content is for entertainment and informational purposes only. Gambling involves risk. Please wager responsibly.