Welcome to Cardiology Today – Recorded November 25, 2025. This episode summarizes 5 key cardiology studies on topics like clonal hematopoiesis and risk communication. Key takeaway: Colchicine Influences Clonal Hematopoiesis Dynamics.

Article Links:

Article 1: Remnant Cholesterol as an Independent Cardiovascular Risk Factor in Young Adults: An Age-Stratified Cohort Study. (Journal of the American College of Cardiology)

Article 2: Age and Sex-Specific Percentiles of 30-Year Cardiovascular Disease Risk Based on the PREVENT Equations. (Journal of the American College of Cardiology)

Article 3: Blood Pressure After Changes in Light-to-Moderate Alcohol Consumption in Women and Men: Longitudinal Japanese Annual Checkup Analysis. (Journal of the American College of Cardiology)

Article 4: Colchicine and Longitudinal Dynamics of Clonal Hematopoiesis: An Exploratory Substudy of the LoDoCo2 Trial. (Journal of the American College of Cardiology)

Article 5: Noninvasive Assessment of Mean Pulmonary Artery Pressure: a Comparison of Doppler Echocardiographic Methods. (Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography)

Full episode page: https://podcast.explainheart.com/podcast/colchicine-influences-clonal-hematopoiesis-dynamics-11-25-25/

Journal: Journal of the American College of Cardiology

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41260759

Summary: This study involving 4308405 participants found that remnant cholesterol is an independent cardiovascular risk factor. It significantly contributes to the residual risk of cardiovascular disease beyond low-density lipoprotein cholesterol across various age groups. The data demonstrated this association with major adverse cardiovascular events, particularly highlighting its relevance even in young adults. This finding underscores the importance of considering remnant cholesterol in cardiovascular risk assessment.

Journal: Journal of the American College of Cardiology

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41260756

Summary: This study developed population-based age and sex-specific percentiles for 30-year cardiovascular disease risk. These percentiles, based on the PREVENT equations, provide a crucial tool for long-term risk assessment in younger adults. The data showed that framing cardiovascular disease risk relative to peers significantly aids in risk communication for both clinicians and patients. This method offers a clear, complementary approach to current absolute risk estimates.

Journal: Journal of the American College of Cardiology

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41123524

Summary: This study analyzed longitudinal data and found specific associations between changes in light-to-moderate alcohol consumption and subsequent blood pressure changes. Results showed that alcohol cessation and initiation distinctly influenced blood pressure levels in both women and men. The data provided sex-specific estimates on these effects, further clarifying the impact across different types of alcoholic beverages. This demonstrates a measurable link between modest alcohol intake modifications and cardiovascular health.

Journal: Journal of the American College of Cardiology

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40892620

Summary: This exploratory substudy of the LoDoCo2 trial found an association between randomization to colchicine and the longitudinal dynamics of clonal hematopoiesis. The data indicated that colchicine, an anti-inflammatory therapy, influences clonal hematopoiesis, a condition associated with increased cardiovascular event risk. The study demonstrated a link between an anti-inflammatory treatment and the dynamics of these aging-related hematologic clones in humans. This offers novel insights into managing clonal hematopoiesis and its cardiovascular implications.

Journal: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41285299

Summary: This study compared several Doppler echocardiographic methods for estimating mean pulmonary artery pressure against right heart catheterization. The data evaluated the yield and agreement of each echocardiographic method in a real-world cohort of 122 patients. Results clarified the performance of noninvasive techniques for pulmonary artery pressure assessment and their correlation with invasive measurements. The findings provide critical information on the reliability and limitations of echocardiography for diagnosing and monitoring pulmonary hypertension.

Today’s date is November 25, 2025. Welcome to Cardiology Today. Here are the latest research findings.

Article number one. Remnant Cholesterol as an Independent Cardiovascular Risk Factor in Young Adults: An Age-Stratified Cohort Study. This study involving 4308405 participants found that remnant cholesterol is an independent cardiovascular risk factor. It significantly contributes to the residual risk of cardiovascular disease beyond low-density lipoprotein cholesterol across various age groups. The data demonstrated this association with major adverse cardiovascular events, particularly highlighting its relevance even in young adults. This finding underscores the importance of considering remnant cholesterol in cardiovascular risk assessment.

Article number two. Age and Sex-Specific Percentiles of 30-Year Cardiovascular Disease Risk Based on the PREVENT Equations. This study developed population-based age and sex-specific percentiles for 30-year cardiovascular disease risk. These percentiles, based on the PREVENT equations, provide a crucial tool for long-term risk assessment in younger adults. The data showed that framing cardiovascular disease risk relative to peers significantly aids in risk communication for both clinicians and patients. This method offers a clear, complementary approach to current absolute risk estimates.

Article number three. Blood Pressure After Changes in Light-to-Moderate Alcohol Consumption in Women and Men: Longitudinal Japanese Annual Checkup Analysis. This study analyzed longitudinal data and found specific associations between changes in light-to-moderate alcohol consumption and subsequent blood pressure changes. Results showed that alcohol cessation and initiation distinctly influenced blood pressure levels in both women and men. The data provided sex-specific estimates on these effects, further clarifying the impact across different types of alcoholic beverages. This demonstrates a measurable link between modest alcohol intake modifications and cardiovascular health.

Article number four. Colchicine and Longitudinal Dynamics of Clonal Hematopoiesis: An Exploratory Substudy of the LoDoCo2 Trial. This exploratory substudy of the LoDoCo2 trial found an association between randomization to colchicine and the longitudinal dynamics of clonal hematopoiesis. The data indicated that colchicine, an anti-inflammatory therapy, influences clonal hematopoiesis, a condition associated with increased cardiovascular event risk. The study demonstrated a link between an anti-inflammatory treatment and the dynamics of these aging-related hematologic clones in humans. This offers novel insights into managing clonal hematopoiesis and its cardiovascular implications.

Article number five. Noninvasive Assessment of Mean Pulmonary Artery Pressure: a Comparison of Doppler Echocardiographic Methods. This study compared several Doppler echocardiographic methods for estimating mean pulmonary artery pressure against right heart catheterization. The data evaluated the yield and agreement of each echocardiographic method in a real-world cohort of 122 patients. Results clarified the performance of noninvasive techniques for pulmonary artery pressure assessment and their correlation with invasive measurements. The findings provide critical information on the reliability and limitations of echocardiography for diagnosing and monitoring pulmonary hypertension.

Thank you for listening. Don’t forget to subscribe.

clonal hematopoiesis, risk communication, right heart catheterization, colchicine, alcohol consumption, low-density lipoprotein cholesterol, pulmonary hypertension, sex-specific percentiles, remnant cholesterol, young adults, major adverse cardiovascular events, Doppler echocardiography, cardiovascular risk factor, noninvasive assessment, cardiovascular events, sex-specific estimates, anti-inflammatory therapy, PREVENT equations, blood pressure, cardiovascular disease risk, alcohol cessation, LoDoCo2 trial, alcohol initiation, pulmonary artery pressure, age-specific percentiles.

Concise summaries of cardiovascular research for professionals.

Subscribe • Share • Follow

The post Colchicine Influences Clonal Hematopoiesis Dynamics 11/25/25 first appeared on Cardiology Today.