The Colts lead this series 12-6 overall against the New York Giants. 10-6 in the regular season and 2-0 in the postseason. (pre-Super Bowl ERA) Daniel Jones for the Giants vs. Who for Indianapolis is the question. The Colts lost in primetime in week XVI, while New York lost on Christmas Eve afternoon. Only the Giants are playoff hopeful and this 19th game of all time against the Colts is a must win for the G-men.