Vidcast:  https://youtu.be/qLlXBwR9aCI

 

The Pfizer mRNA vaccine and the Johnson and Johnson adenovirus vector vaccine induce comparable rises in anti-CoVid antibodies and anti-Covid cellular immunity after initial Pfizer vaccination.  In another words, a mix and match boosting strategy works!  Researchers at Harvard and the University of North Carolina report these results after analyzing the immunity conferred on 65 subjects, 24 of whom received the Pfizer and 41 received the J&J.

 

By 6 months after Pfizer vaccination, antibody protection against CoVid variants compared with the original strain plummets significantly.  Two and four weeks after a boost of either the J&J vaccine or the Pfizer vaccine, the antibody protection against all CoVid strains bumps up though protection against Omicron does begin to wane quickly.

 

Looking at cellular immunity against CoVid, the analysis showed that this part of the immune response remained quite active even 6 months following the initial Pfizer vaccination.  Boosting with the J&J virus vector vaccine did drive cellular immunity higher than with the Pfizer vaccine.

 

The bottom line: you can successfully mix and match when boosting your initial vaccination with an mRNA vaccine such as Pfizer and Moderna.  Those vaccinated with either mRNA vaccine, Pfizer or Moderna, should receive a booster of mRNA vaccine by 6 months after the second shot.  Those vaccinated with the J&J vaccine should receive a booster of mRNA vaccine 2 months after the J&J shot remains in place

 

This and other studies show that anti-Omicron cellular immunity remains robust after initial vaccination with mRNA vaccines.  This may well be the reason that those who do develop breakthrough Omicron experience relative mild cases.

 

https://www.medrxiv.org/content/10.1101/2021.12.02.21267198v2.full.pdf

 

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