Diabetes Knowledge into Practice Podcast

Considerations for offering GLP-1 RAs | With Prof. Carel Le Roux


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The GLP-1 receptor agonist class offers multifactorial benefits, including reductions in blood glucose, weight loss and cardiovascular protection. But do these vary across the class, and which patients should be offered one? And given they also carry a high risk of gastrointestinal side effects, how should we approach initiating therapy? Join us for a conversation with Prof. Carel Le Roux, Professor of Experimental Pathology and Co-Director of the Metabolic Medicine Group at University College Dublin, and Reader in Investigative Science at Imperial College London.

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Disclosures:

Professor Carel Le Roux has been an advisory board member for Boehringer Ingelheim, Herbalife, GI Dynamics, Johnson & Johnson, and Novo Nordisk.

References:

  • Trujillo J et al. Ther Adv Endocrinol Metab. 2021 Mar;12
  • American Diabetes Association. Diabetes Care 2021; 44(Supplement 1)
  • Buse J et al. Diabetes Care. 2020 Feb;43(2):487-493
  • Marso S et al. N Engl J Med. 2016 Jul 28;375(4):311-22 [LEADER]
  • Marso S et al. N Engl J Med. 2016 Nov 10;375(19):1834-1844 [SUSTAIN 6]
  • Hernandez A et al. Lancet. 2018 Oct 27;392(10157):1519-1529 [Harmony Outcomes]
  • Gerstein H et al. Lancet. 2019 Jul 13;394(10193):121-130 [REWIND]
  • Husain M et al. N Engl J Med. 2019 Aug 29;381(9):841-851 [PIONEER 6]

  • Funding statement:

    This independent educational activity is supported by an educational grant from Eli Lilly, Merck Sharp and Dohme Corp. and Novo Nordisk A/S. The educational content has been developed by Liberum IME in conjunction with an independent steering committee; the financial supporters have had no influence on the content of this education.

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