Research exploring creatine monohydrate suggests that while the supplement is primarily known for enhancing muscle performance, it may also influence brain health and neurological function. One large-scale clinical trial specifically examined whether creatine could slow the progression of Parkinson disease, but the study was terminated early after the supplement failed to show any significant benefit over a placebo. Despite this, other narrative reviews indicate that creatine may still hold promise for improving cognitive function during periods of stress, such as sleep deprivation, or for managing symptoms of depression and traumatic brain injury. While the brain appears more resistant to external creatine uptake than skeletal muscle, supplementation can successfully increase cerebral creatine levels to a modest degree. However, current evidence remains inconsistent regarding its effectiveness for chronic neurodegenerative diseases, necessitating further research into optimal dosing strategies. Together, these sources provide a comprehensive look at the therapeutic potential and limitations of using creatine to support the central nervous system.