Androgen receptor (AR) signaling has long been the central driver of prostate cancer progression and the primary target of therapies for advanced disease. Yet, a significant subset of tumors either fail to respond or develop resistance, often by switching to AR-independent programs that resemble basal or stem cell-like states. Understanding what drives these aggressive, therapy-resistant phenotypes is a critical challenge in oncology.

A research paper, titled “CREB5 regulates stem cell-like transcriptional programs to enhance tumor progression in prostate cancer” was published in Volume 17 of Oncotarget by a multi-institutional team of researchers, identifies a key molecular regulator of this process and reveals how it promotes tumor progression.

Full blog - https://www.oncotarget.org/2026/04/07/creb5-a-master-regulator-of-stem-cell-like-programs-in-prostate-cancer-progression/

Paper DOI - https://doi.org/10.18632/oncotarget.28826

Correspondence to - Emmanuel S. Antonarakis - [email protected], Justin Hwang - [email protected]

Abstract video - https://www.youtube.com/watch?v=Zywrj5hV4ho

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Keywords - cancer, prostate cancer, CREB5, basal-like, stem cell-like, AP-1 transcription factors

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