<p>Explore the shift from standard Cas9 nuclease—which makes double-strand breaks—to precision tools like Cas9 nickases (single-strand “nicks”) and dead Cas9 (binding without cutting). We break down how these variants reduce off-target indels and enable safer editing and gene regulation (CRISPRi/a, base/prime editor scaffolds) for high-fidelity genome engineering.</p>

Explore the shift from standard Cas9 nuclease—which makes double-strand breaks—to precision tools like Cas9 nickases (single-strand “nicks”) and dead Cas9 (binding without cutting). We break down how these variants reduce off-target indels and enable safer editing and gene regulation (CRISPRi/a, base/prime editor scaffolds) for high-fidelity genome engineering.

CRISPR–Cas9 Variants for High-Fidelity Genome Editing

GeneInCell-The AI-powered Biotech Podcast focuses on crisp, science-based podcasts on stem cells, organoids, and gene editing—tracking breakthroughs from bench to bedside for better human health, including Biotech and business.

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CRISPR–Cas9 Variants for High-Fidelity Genome Editing

CRISPR–Cas9 Variants for High-Fidelity Genome Editing