In collisions of ultra-intense laser-pulse with relativistic electrons as well as in ultra relativistic heavy ion collisions at RHIC and at LHC it is possible to probe critical acceleration a=mc^3/hbar. The behavior of a particle undergoing critical acceleration challenges the limits of the current understanding of basic interactions: little is known about this physics frontier; both classical and quantum physics will need further development in order to be able to address this newly accessible area of physics. The problem of critical acceleration is closely connected to strong field particle production, Mach's Principle, Unruh and Hawking radiation.