This release contains only the music track from Base by Base Episode 389.

Song title: Crotonylation, Hold the Line
Original Base by Base episode: 389: Crotonylation impedes c-Myc oncogenic activity

Article metadata:
Article title: Crotonylation impedes c-Myc oncogenic activity
Journal: PNAS
DOI: 10.1073/pnas.2530020123
Reference: https://doi.org/10.1073/pnas.2530020123

Lyrics:
Verse 1
Under white lights, the signals start to spark,
A switch on a protein in the dark.
A tiny mark where the messages align,
And suddenly the noise learns how to decline.

Pre-Chorus
Hands on the bench, eyes on the screen,
A lock clicks shut where it shouldn’t have been.
If the grip is broken, the storm can slow,
One quiet change in the afterglow.

Chorus
Crotonylation, hold the line,
Keep that wildfire from crossing the signs.
K289, K298—stay in place,
Let the runaway lose the race.
Crotonylation, hold the line.

Verse 2
When the mark is missing, the binder comes close,
Skp2 pulls tight like a knot in a rope.
The pages turn faster, the volume climbs,
More genes lit up in relentless time.

Bridge
And there’s a variant turning the key—K298N,
Less of the mark, and the pull begins.
In living tissue the shadow can grow,
But the map says where the pressure flows.
Break the handshake, change the deal,
Turn down the drive, make the damage kneel.

Final Chorus
Crotonylation, hold the line,
Keep that wildfire from crossing the signs.
K289, K298—stay in place,
Let the runaway lose the race.
Cut the Skp2 chain in time,
Crotonylation—hold the line.