In the metabolism of certain medications

They’re found in the liver and throughout the body

And they’re the star of this song today, so congratulations

Drug interactions are what you have to watch out for

‘Cause these enzymes’ activity can be affected

By certain drugs and compounds, inducers or inhibitors

And the effect of this on other meds is connected

This mnemonic is all you need to remember

The inducers of Cytochrome P450

“This CRAP GPS induces my rage”

“This CRAP GPS induces my rage” — pretty nifty

Now let’s break it down:

C for Carbamazepine

R for Rifampin

A for Alcohol, chronic use

P for Phenytoin

G for Griseofulvin

P for Phenobarbital

S for Sulfonylureas

These inducers increase the production and activity

of the Cytochrome P450 isoenzymes

This increases drug metabolism

Which can cause a sub-therapeutic effect oftentimes

This mnemonic is all you need to remember

The inducers of Cytochrome P450

“This CRAP GPS induces my rage”

“This CRAP GPS induces my rage” — pretty nifty

Now let’s break it down:

C for Carbamazepine

R for Rifampin

A for Alcohol, chronic use

P for Phenytoin

G for Griseofulvin

P for Phenobarbital

S for Sulfonylureas

And on a test if a drug or compound isn’t an inducer

Then it's likely an inhibitor by process of elimination

Inhibitors decrease Cytochrome P450 activity

Which can lead to toxic drug levels and higher concentration

But just memorize the inducers

And then you’ll be good to go

“This CRAP GPS induces my rage”

Now you're a pharmacology pro

This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thesingingstethoscope.substack.com