Jim Surmeier (Northwestern University) talks to us about integrating circuit, ion channel and bioenergetic vantage points to define quantitative, neuron-specific mechanisms of pathology in Parkinson’s disease. He guides the group through a discussion of how his hypothesis-driven approach is informing an exciting new clinical trial for slowing the progression of Parkinson’s disease.

Duration: 47 minutes

Discussants:(in alphabetical order)

Alfonso Apicella (Asst Prof, UTSA)

Salma Quraishi (Res Asst Prof, UTSA)

Asif Maroof (Asst Prof, UTSA)

Carlos Paladini (Professor, UTSA)

Todd Troyer (Assoc Prof, UTSA)

Matt Wanat (Asst Prof, UTSA)

Charles Wilson (Ewing Halsell Chair, UTSA)

acknowledgement: JM Tepper for original music.