We discuss Jacob's career going from physics to biology and making the transition from academia to industry. Building and leading data science teams at GNS Healthcare, Indigo, and now EQRx, Jacob is one of the best data scientists in biotech. In our conversation, we talk about ways to generate standardized data for machine learning models, building interdisciplinary teams, and implementing relevant models for drug development.  Then we touch on EQRx's fast follower drug development model and the role of data in integrating decision making across the board from target ID to commercialization. A favorite quote of mine from talking to Jacob was: "things don't change much until they change all at once."