The ability for information services to continue operating despite attacks is a core enabler of mission assurance goals. Existing security techniques lack this concept of resilience and are inadequate for protecting critical services and data against targeted attacks by sophisticated adversaries. Widely implemented signature and anomaly-based detection techniques fail to keep pace with the advancement of attacker sophistication. Our objective is to develop and prototype resilience techniques that make applications impervious to the damaging effects of attacks without relying on identifying and filtering specific attacks. We employ effects-based countermeasures to impart resilience to applications, creating an environment inhospitable to attack goals, and countering previously unknown attacks on service utility, in particular, code injection and data subversion.