The sermon focuses on Colossians 3 and the concept of dying to our old selves to live a new life in Christ. It emphasizes the need to desire, decide, declare, and deliver the old ways as dead. The message also highlights the importance of accountability and community in this spiritual journey, as well as the necessity of suffering and sacrifice in following Christ. The ultimate goal is to live a life that is dead to sin and alive in Christ, reflecting His holiness and righteousness.