Jack West (@JackWestMD), MD, City of Hope Comprehensive Cancer Center, and Nathan Pennell (@n8pennell), MD, PhD, Cleveland Clinic, debate the results of the ADAURA trial presented as a plenary session at the 2020 ASCO virtual meeting, especially the extrapolation from DFS to OS, balance of chemotherapy administration in the treatment arms, lumping of varying disease stages in treatment arms, and severity of toxicity issues.