In this month's Cell Podcast, we learn about why structural biologists need no longer fear the membrane, with Doug Rees (Tirado-Lee et al. and Special Reviews Collection) (0:00), why epithelial biology is going 3D (glasses not included), with Ian Macara (McCaffrey et al. and Special Issue of Trends in Cell Biology) (8:42), and how sperm cells get their epigenetic message across, with Philippe Collas (Lindemann et al.) (13:54).