JACI: In Practice Editor Scott Sicherer describes the December issue, the theme of which is “Anaphylaxis”. Theme topics covered include idiopathic anaphylaxis, alpha-tryptase overexpression, and various aspects of epinephrine therapy, including safety, prescribing and deprescribing, public availability, and the intranasal form. Dr. Sicherer then presents the Highlights of the Original Articles in the issue, which are on the topics of Anaphylaxis, Asthma, Drug Allergy, Eosinophilic Disorders, Food Allergy, Immunotherapy, Pediatric Allergy, Rhinosinusitis, and Urticaria