Join us on a deep dive into the world of generalized anxiety disorder (GAD) with Dr. Khalsa. This episode unravels the intricacies of how our body perceives internal sensations, especially during heightened moments of anxiety. Why do some individuals feel their heart race or breath quicken more intensely than others? Using a groundbreaking study, Dr. Khalsa investigates how those with GAD respond to β-adrenergic stimulation, a key driver of such symptoms. Leveraging advanced neuroimaging, the research uncovers a distinct relationship between GAD, heart palpitations, dyspnea, and activity in the ventromedial prefrontal cortex. Discover the potential implications of these findings for future treatments, and gain a deeper understanding of the physiological and neural intricacies that characterize GAD. If you've ever been curious about the science behind anxiety or wondered about the internal mechanisms that shape our emotional experiences, this episode promises a captivating exploration into the heart of GAD. http://jamanetwork.com/article.aspx?doi=10.1001/jamapsychiatry.2021.4225