The Ropes & Gray Decoding Digital Health podcast series discusses the digital health industry and related legal, business and regulatory issues. In this inaugural episode, the co-leads of the Ropes & Gray Digital Health Initiative, Megan Baca, Kellie Combs and Christine Moundas, take a multidisciplinary approach to exploring trends and hot topics for 2021 related to their transactional, FDA regulatory and health care practices. Many of the topics covered in this initial episode will be further discussed and explored throughout the series, including developments in artificial intelligence, big data and interoperability considerations, as well as regulations and guidance around telehealth, software as a medical device, and use of real-world evidence.