Dive into the microscopic realm of neural progenitor cells with Dr. Ernst of McGill University as we delve into the intricacies of FOXG1—a gene exclusively expressed in the brain—and its profound implications. From microcephaly to severe intellectual disabilities, the role of FOXG1 is more integral than previously thought. In a groundbreaking study, Dr. Ernst and his team meticulously modeled FOXG1 syndrome using cells from diagnosed patients and controls. The revelations? Cells with a FOXG1 loss demonstrated a marked reduction in proliferation, a skewed cell cycle ratio, and an intriguing increase in primary cilia. But what happens when the FOXG1 gene is manipulated? The engineered loss and subsequent repair of FOXG1 reveal its dose-dependent effects, painting a clear picture of its essential role in human brain cell growth. Whether you're curious about genetic functions in brain health or the potential future therapies for disorders like glioblastoma, this episode with Dr. Ernst promises a deep dive into the genetic heart of our most vital organ.

Keyword List:

McGill University

FOXG1 Syndrome

Neural Progenitor Cells

Microcephaly

Seizures

Intellectual Disability

Glioblastoma

Forebrain Cell Proliferation

Cell Cycle

Primary Cilia

Genetic Engineering

Human Brain Cell Growth

https://doi.org/10.1016/j.stemcr.2022.01.010