The human pathology is that we presume a world that is impossible to live in in any satisfactory way. In the twelve links of dependent co-arising are the Buddha's most comprehensive teaching, in which he explores from a cognitive perspective: our presumptions, how they arise, how they afflict us, and what happens when we let go of them. This is the first in a long series of talks about which the Buddha said, "Whoever sees dependent co-arising sees the Dhamma." These talks supplement a text available as a pdf at: sitagu.org/shortlinks/coarising/ (DCA 1)