This episode provides a comprehensive overview of depression, covering its clinical subtypes, diagnostic considerations, and underlying neurobiological mechanisms. It explores current first-line treatments—including pharmacological and psychotherapeutic approaches—as well as the limitations of focusing solely on specific neurotransmitters. In acknowledging these limitations, attention is given to emerging therapies informed by advances in our understanding of the roles played by inflammation, hormones, neuroplasticity, and metabolism. The episode also reviews nutritional deficiencies, evidence-based supplements, and foundational behavioural strategies that support recovery. Considerable time has been taken to ensure that all relevant and evidence-informed aspects are included, and we hope it serves as a useful resource. Please share it with anyone you feel may benefit.