The movie "Despicable Me" presented us to the villain Gru, along with his gadget expert Doctor Nefarious and his resentful Minions towards Vector, another villain. Margo, Edith, and Agnes are the three orphan females he adopts in order to get inside Vector's stronghold.  Gru develops feelings for the girls and comes to their aid during his battle with Vector. Agent Lucy Wilde from the Anti-Villain League goes to Gru to plead for assistance in recovering a mutagen that El Macho stole in the 2013 film "Despicable Me 2." Gru first declines because he's become a responsible father, but after Doctor Nefarious departs to become even more evil, the mutagen is applied to the Minions. To the surprise of the girls, Lucy and Gru form a friendship as they fight and eventually get married.

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