This podcast explores the groundbreaking CORA system developed by the medical technology start-up AccuLine, which aims to revolutionize the early detection of coronary artery disease (CAD). Designed for primary care settings, the CORA system is a non-invasive, point-of-care diagnostic tool that uses artificial intelligence to analyze a patient's electrical cardiac activity, blood oxygen levels, and respiratory rate during a simple four-minute resting exam. The discussion highlights the severe limitations and inaccuracies of traditional stress tests, contrasting them with CORA's impressive recent clinical trial results in Israel, where the technology achieved a 94% sensitivity and a 99% negative predictive value in ruling out CAD against the gold standard of invasive angiography. Finally, the episode touches upon AccuLine's strategic collaboration with the Mayo Clinic and its upcoming 2,000-patient U.S. clinical trial, which will pave the way for anticipated FDA clearance and future commercial availability in the United States.