In this episode we discuss a report from the Jacobsen lab on an enantioselective synthesis of difluorinated alkyl bromides catalyzed by a chiral iodoarene. Linear free energy relationships between experimental enantioselectivities and computed catalyst parameters helped elucidate the origins of enantioselectivity. 
DOI: 10.1021/jacs.0c07043

In this episode we discuss a report from the Jacobsen lab on an enantioselective synthesis of difluorinated alkyl bromides catalyzed by a chiral iodoarene. Linear free energy relationships between experimental enantioselectivities and computed catalyst parameters helped elucidate the origins of enantioselectivity. DOI: 10.1021/jacs.0c07043

In this episode we discuss a report from the Jacobsen lab on an enantioselective synthesis of difluorinated alkyl bromides catalyzed by a chiral iodoarene. Linear free energy relationships between experimental enantioselectivities and computed catalyst parameters helped elucidate the origins of enantioselectivity.&nbsp;
DOI: 10.1021/jacs.0c07043

Difluorinated Alkyl Bromide Synthesis via Chiral Iodoarene Catalysis

The Cyclo Edition is the podcast for those looking to go above and beyond in their understanding of organic chemistry literature. In each episode we break down a recently published paper and detail the background, explain the breakthrough, and analyze the broader impacts of the paper on the field.

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Difluorinated Alkyl Bromide Synthesis via Chiral Iodoarene Catalysis

Difluorinated Alkyl Bromide Synthesis via Chiral Iodoarene Catalysis