In an article published in the March 2013 issue of PTJ, Daniel Martins and colleagues found that ankle joint mobilization (AJM) decreased postoperative mechanical hyperalgesia in mice and that this effect was prevented by treatment of the mice with caffeine. In this podcast, 3 of the authors of the study--Daniel Martins, Leidiane Mazzardo-Martins, and Adair Santos--join moderator Kathleen Sluka and Joel Bialosky to discuss the study findings as well as the benefits and pitfalls of using animal models of pain. The group also discusses how the outcomes of studies of animal models can be translated into human studies.