According to the literature, people with multiple sclerosis (MS), as a group, are sedentary and inactive compared with the general population. What variables explain this inactivity? In their longitudinal study, "Longitudinal Change in Physical Activity and Its Correlates in Relapsing-Remitting Multiple Sclerosis" (August 2013), Robert Motl and colleagues found that, in people with relapsing-remitting MS, the primary predictor of change in long-term patterns of physical activity was change in self-efficacy (confidence in ability to be physically active) rather than commonly cited factors such as fatigue, depression, or pain. In this podcast, lead author Robert Motl, PhD, clinical expert Anne McCarthy Jacobson, PT, DPT, MS, and moderator Kathleen Gill-Body, PT, PhD, discuss the clinical implications of these findings and the challenges and the feasibility of teaching self-efficacy in this patient population. They also cover new ways to deliver self-efficacy interventions outside of a structured office visit.