Recent research has shown that increased brain neuroplasticity is a key element in recovery of motor function after stroke and that brain-derived neurotrophic factor (BDNF) is a key facilitator in neuroplasticity. In a recent PTJ Perspective article (December 2013), which Steven Wolf calls "remarkably timely" for clinicians and students, Cameron Mang and colleagues examined how aerobic exercise could be used to increase the secretion of BDNF and thus "prime the brain for neuroplasticity." They also looked at how genetic variations affect the production of BDNF. In this PTJ podcast, authors Cameron Mang and Lara Boyd join Steven Wolf and moderator James Carey to discuss the role of aerobic exercise in enhancing neuroplasticity and how genetic variation can affect the response of a patient to poststroke rehabilitation. The group also discusses the amount and intensity of exercise needed to increase BDNF secretion and the future directions for research.