In the June 2013, PTJ published “Immediate Effects of Region-Specific and Non–Region-Specific Spinal Manipulative Therapy in Patients With Chronic Low Back Pain: A Randomized Controlled Trial.” This RCT contributed to the growing body of evidence that suggests that spinal manipulative therapy is a viable treatment option for low back pain; however, the results did not differ regardless of whether a region-specific or non-region-specific technique was used. In this podcast, manual therapy expert Chad Cook and moderator Steven George join the article’s senior author Leonardo Costa to discuss the study findings and their possible clinical implications. Are we close to understanding the mechanisms of action for this intervention? What are the next steps in research?