Developed at the Wyss, FISSEQ (fluorescent in situ sequencing) is a spatial gene sequencing technology that reads and visualizes the three-dimensional coordinates of RNA and mRNAs – the working copies of genes – within whole cells and tissues. FISSEQ affords insights into biological complexity that until now have not been possible.

In this episode of Disruptive, Wyss Core Faculty member George Church, Wyss Senior Staff Scientist Rich Terry, and former Wyss Entrepreneur-in-Residence Shawn Marcell discuss FISSEQ's development and translational potential, which could be used to advance the development of diagnostics and discovery of new drug targets.