Cities are increasingly driving the global economy. Yet there are numerous disruptive forces that threaten to deepen inequality and economic exclusion unless cities adapt and evolve. The choices that municipal leaders make today to give the workforce access to skills, foster innovation and entrepreneurship, and deepen regional connections will have long-term implications for their cities’ economic development. How can cities achieve broader, more inclusive economic development in the face of large scale changes in urbanization, globalization, technology, and demographics? What local solutions can be found to address these global forces of disruption?