In this episode, we dive into the complex issue of diuretic resistance in congestive heart failure (CHF), focusing especially on loop diuretics. We break down how these medications work, why they sometimes stop working, and the physiological mechanisms behind resistance including post-diuretic sodium retention, the braking phenomenon, and cardiorenal syndrome. You'll also hear about evidence-based strategies to overcome resistance, from dietary interventions and dosing adjustments to combination diuretic therapy. Whether you're a clinician or a curious learner, this episode will help you understand why diuretics fail...and what to do about it.