Adipose tissue—particularly visceral adipose tissue (VAT)—is not merely a passive energy store. It is metabolically active and pro-inflammatory, secreting cytokines and adipokines that drive systemic inflammation. It is therefore plausible that reducing VAT may alleviate joint pain by lowering inflammatory signalling, not just mechanical stress. In this article, we explore the hypothesis that weight loss reduces arthritis and joint pain by lowering inflammatory mediator release from VAT, rather than load-bearing mechanics alone.

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