Marshall Segal addresses four common lies that can hinder Bible reading: that the Bible is irrelevant, hard to understand, unhelpful in times of pain, or won't bring happiness. He refutes these misconceptions by emphasizing the Bible's power to provide wisdom, comfort, understanding, and joy. Segal encourages reading Scripture in community, persevering through tough passages, and engaging with the Word prayerfully, recognizing the spiritual battle against distractions and discouragement.