Lichtman created the Keys to the White House model with Soviet seismologist Vladimir Keilis-Borok in 1981. The model uses 13 true/false criteria to predict whether the presidential candidate of the incumbent party will win or lose the next election. Using this model, Lichtman has accurately predicted the winner of every U.S. presidential election since 1984, with the exception of 2000, although he did forecast successfully that Al Gore would win the popular vote that year. He ran for the U.S. Senate seat from Maryland in 2006, finishing in sixth place in the Democratic primary. In 2017, Lichtman published The Case for Impeachment, laying out multiple arguments for the impeachment of Donald Trump.