How can we reduce preventable deaths on a population level? What are health outcomes research, precision population health, and big data; and how can we utilize these to improve the public's health? What do we hope to learn from the Yale Paxlovid for Long COVID Trial, and how will the finidngs improve patients' lives in real-time? How much of a problem is health misinformation and what can we do to reduce it? We discuss these topics and more with Dr. Harlan Krumholz, Professor and Director of the Yale Center for Outcomes Research & Evaluation (CORE).