One of Darwin's original drawings of an evolutionary tree had "I think" written next to it. Dr. Luay Nakhleh explains how evolution underlies much, or perhaps all, of bioinformatics analyses. This includes his own research where he computationally models the evolutionary process, with a focus on cases where evolution violates Darwin's original assumption that evolution mirrors the shape of a tree. Dr. Nakhleh explains how he tackles the problem of modeling these complex evolutionary processes, including in cancer genomics.