In the third episode of The Rising Tide Podcast, Dr. Madhuri Hegde, Perkin-Elmer’s Chief Scientific Officer, and co-author on the 2015 "Standards and Guidelines for the Interpretation of Sequence Variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics, and the Association for Molecular Pathology," sits down with the Center for Genomic Interpretation to discuss past and future guidelines and considerations for variant classification.