What if the biggest risk factor for cancer, heart disease, and dementia isn't your genes, diet, or blood pressure but aging itself? Listen in as biogerontologist Dr. Matt Kaeberlein reveals how understanding the biology of aging could add not just years to our lives, but healthy decades, and why your dog might hold some of the most important clues.

In this episode, Therese Markow and Dr. Matt Kaeberlein discuss aging research. He explains that aging is characterized by damage accumulation and loss of resilience, leading to functional decline. Matt highlights the hallmarks of aging, such as deregulation of nutrient sensing and DNA damage, and the potential of interventions like rapamycin to slow aging. He notes that biological age is a significant risk factor for major diseases, and that understanding and addressing aging biology could significantly extend human lifespan. They also discuss the Dog Aging Project, with 55,000 participating dogs, which aims to uncover genetic and environmental factors influencing health and longevity in pets.

Key Takeaways:

• Our bodies are constantly being exposed to stress, and stress can move us out of the optimal zone of function. When we're young, we're very resilient and able to come back to optimal function. As we get older, we lose that resilience.

• When we slow aging in laboratory animals, we prevent the onset and progression of all of the major age-related functional declines and diseases simultaneously, because we've slowed biological aging. Based on what's possible in mice, it is estimated that we could potentially gain 2-3 additional decades of life if we can achieve this in humans.

• There is a genetic component to longevity; however, how big that genetic component is to longevity is hotly debated. The environment is also a large contributor.

"Biological age is the single greatest risk factor for nine of the top 10 killers in the United States, and it's not a small effect. The magnitude of effect from biological aging dwarfs all of the other risk factors combined…it's useful to appreciate how important biological age is to the risk of developing many of the chronic diseases and functional declines that limit quality and quantity of life for most people." — Dr. Matt Kaeberlein

Episode References:

• Dog Aging Project: https://dogagingproject.org/

• Dog Aging Institute: https://dogaginginstitute.org/

• Longevity for Dogs: https://www.youtube.com/@LongevityForDogs

Connect with Dr. Matt Kaeberlein:

Professional Bio: https://halo.dlmp.uw.edu/people/matt-kaeberlein/

Publications: https://pubmed.ncbi.nlm.nih.gov/?term=%22kaeberlein+m%22[author]

YouTube: https://www.youtube.com/@mkaeberlein

LinkedIn: https://www.linkedin.com/in/mkaeberlein/

Connect with Therese:

Website: www.criticallyspeaking.net

Bluesky: @CriticallySpeaking.bsky.social

Instagram: @criticallyspeakingpodcast

Email: [email protected]

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