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Episode Summary

From surgeon to psychiatrist, Bitcoin investor to billion-dollar crypto brokerage founder, Dr. Prash Puspanathan has lived one of the most unconventional founder journeys in tech. After co-founding and scaling Caleb & Brown into a global crypto powerhouse, later acquired by SwiftX in 2025, Dr. Prash is now pioneering the future of mental health with Enosis Therapeutics, using VR to transform psychedelic-assisted therapy integration.

In this episode of Perspective X, Dr. Prash shares how a single psilocybin experience completely reshaped his worldview, steering him away from surgery and into psychiatry, entrepreneurship, and eventually, crypto. He reveals the parallels between fiscal freedom in decentralized finance and cognitive freedom in mental health, the scrappy early days of arbitrage trading, and the challenges of scaling a white-glove brokerage to serve high-net-worth clients worldwide.

We also dive into the future of psychedelic medicine, why integration is the “real work,” how technology can lower costs and increase access, and why prevention, not just treatment, will define the next era of mental health. From paradigm-shifting psychedelics to building billion-dollar ventures, this is a conversation about liberation, of thought, finance, and human potential.

Time Stamps

00:00 – Intro: Dr. Prash’s unconventional founder journey

02:00 – From surgery to psychiatry: psychedelics as a turning point

06:30 – The transformative psilocybin experience and shifting paradigms

10:30 – Understanding psychedelic therapy and integration work

16:00 – Why psychedelics challenge power structures and cultural norms

22:00 – Fiscal freedom and cognitive freedom: psychedelics and Bitcoin

30:00 – Founding Caleb & Brown and building a billion-dollar brokerage

37:00 – Global scaling, high-net-worth clients, and leadership transitions

42:00 – Preparing for acquisition: the 9-month journey to SwiftX

50:00 – Running a dual life as psychiatrist and founder

55:00 – Enosis Therapeutics: VR-powered integration for psychedelic therapy

01:02:00 – Building tools for patients, therapists, and the future of mental health

01:10:00 – The vision for a psychological digital twin

01:15:00 – Psychedelics in the next 10–50 years: from treatment to prevention

01:20:00 – Translating research into real-world impact and future mission

Resources

💰 Caleb & Brown – Global crypto brokerage: https://calebandbrown.com

🩺 Enosis Therapeutics – Tech for psychedelic-assisted therapy: https://www.enosistherapeutics.com/

👤 Dr. Prash on LinkedIn: https://www.linkedin.com/in/drprash/

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