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Summary:  It’s happening, almost always happening - drug interactions.  But is the drug-drug interaction significant?  And is it intended, using the primary mechanism of action or side effects of one drug along with another drug’s effects to achieve the desired result?  Or is it a potential problem, the risks and benefits assessed, with monitoring in place, to guide the management of the drug-drug interaction?  What the body does to the drugs and what the drugs do to the body is where these drug-drug and drug-nutrient interactions occur.  This episode provides an overview of this, with the idea being to better understand and more effectively communicate with your physician and pharmacist about these issues. 

Topics Covered: 

·      Drug Interactions 03:50

·      Pharmacokinetics - Absorption 04:58

·      Tetracycline Absorption Interactions 05:15

·      Sucralfate 06:08

·      Metoclopromide  07:07

·      Dangerous Drug-Drug Interactions 08:20

·      Intended Drug-Drug Interactions 09:02

·      Probability, Severity and Management 09:45

·      Precautions 10:00

·      Contraindications 10:20

·      Xarelto and Heparin 11:00

·      Pharmacokinetics – Distribution 11:35

·      Protein Binding  12:15

·      Phenytoin and Diazepam 12:30

·      Pharmacokinetics – Elimination 13:15

·      Methotrexate and NSAIDS 13:23

·      Lithium and Table Salt 14:00

·      Pharmacokinetics – Metabolism, Statins and Grapefruit 14:55

·      Liver Enzymes:  Inducers and Inhibitors 15:30

·      Pharmacodynamics 16:28

·      Desired Additive Mechanisms of Action 17:01

·      Undesired Additive Side Effects 18:49

·      Concerns? 20:00 

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