Niesha Griffith, RPh, MS, FASHP, interim chief pharmacy officer and executive director at a freestanding cancer center on the West Coast, and Michael Ganio, PharmD, MS, BCPS, FASHP, director of pharmacy practice and quality, American Society of Hospital Pharmacists (ASHP), provide varying perspectives on the potential of drug shortages (eg, pain medications, cancer therapies, and hydroxychloroquine) emerging during the COVID-19 pandemic, as well as how the supply chain functions through the ASHP when a shortage is identified.