Perioperative antibiotics are part of nearly every anesthetic — but how often do we stop to ask why a specific antibiotic was chosen? In this episode, Cole and Tanner break down perioperative antibiotic prophylaxis from an anesthesia perspective, including selection, timing, common contraindications, and what to do when allergies or red flags arise. A practical discussion to help you move beyond “that’s just what we give” and make more informed, patient-specific decisions in the OR.