The Y in Psychiatry

E18 - The Bipolar Brain on Overdrive: Dopamine, Serotonin & Circuits


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In this episode of The Y in Psychiatry, Dr. Amayo, Dr. V Handratta, and Dr. Nguyen take bipolar disorder off the DSM page and into your brain, but through your ears. They explain through tracing how dopamine and serotonin imbalances map onto psychomotor agitation, depression, and that “too much energy” feel of mania. They fly through the basal ganglia–thalamus–sensorimotor loop, the ventrolateral and ventromedial prefrontal cortex, the amygdala, and the superior frontal gyrus to show how disrupted circuits drive impulsivity, hyperemotionality, and goal-directed behavior. Say that 10 times. Along the way, they drop practical mnemonics, callbacks to network neuroscience, and framing you can use at the bedside or on rounds—no fMRI in clinic required.

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The Y in PsychiatryBy NguyenInDoubt

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